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1-3H3/b5-4+
OC[C@H]1O[C@@H](OC2=CC3=C(C=C(O)C=C3O)[O+]=C2C2C=CC(O)=CC=2)[C@H](O)[C@@H](O)[C@H]1O
Smiles: CC1=NN(C2=CC(NCCCOCCOCCOCCOCCOCCCNCC3C=CC(=CC=3)/C(/C=C/C3=[N+](CCCCS([O-])(=O)=O)C4=CC=CC=C4C3(C)C)=C\C=C3\N(CCCCS(O)(=O)=O)C4=CC=CC=C4C\3(C)C)=C(C=C2)C(N)=O)C2CC(C)(C)CC(=O)C1=2
Halfmann P
CAS Number: 252025-52-8
GNF-6231 0636457-O-C3-COOH 1-3H3/b5-4+GNF 6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling. 1) GNF 6231 shows IC50s of greater than 10 M on all CYP isoforms tested2) GNF 6231 have favorable potency and a PK profile across preclinical species upon oral administration. 3) The reference for orally in MMTV Wnt1 tumor bearing mice is dosed at 3 mg kg. 4) GNF 6231 showed very robust dose related antitumor efficacy. Product information CAS